Kang Lab
Princeton University
Metastasis is responsible for most of cancer deaths. The mission of our laboratory is to apply modern molecular biology, genomics, and computational b
Field(s) of Research: Cancer, Genomics
Disease Focus: Breast Cancer, Prostate Cancer
Website: http://www.molbio1.princeton.edu/kang/
LabLife URL: http://www.lablife.org/labs/3242
 
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Contact Us
Email: ykang@princeton.edu
Phone: 609-258-8834
Fax: 609-258-2340
Address:
LTL255, Washington Road
Princeton University
Princeton, NJ 08540
United States
Lab Members
Research
Molecular mechanism of cancer metastasis
Metastasis, the spread of cancer cells from the primary tumor to distant organs, is the most dreadful development of neoplastic diseases. The mission of our laboratory is to apply modern molecular biology, genomics, and computational biology approaches to understand the molecular basis of cancer metastasis. Major areas of research in our laboratory includes: identification and functional characterization of metastasis genes, pre-clinical evaluation of anti-metastasis therapeutics, development of advanced imaging technology and non-invasive detection of tumor-stroma interaction during metastasis, the role of miRNA in cancer progression and metastasis, molecular characterization of mammary gland stem cells and their link to breast tumor stem cells.
Keywords metastasis, breast cancer, mouse model, in vivo imaging, EMT, miRNAs, mammary gland stem cells

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Publications
Ganapathy V, Ge R, Grazioli A, Xie W, Banach-Petrosky W, Kang Y, Lonning S, McPherson J, Yingling JM, Biswas S, Mundy GR, Reiss M
Mol Cancer. 2010 May 26. 9(1):122.
Lu X, Yan CH, Yuan M, Wei Y, Hu G, Kang Y
Cancer Res. 2010 May 15. 70(10):3905-14.
Matveeva OV, Kang Y, Spiridonov AN, Saetrom P, Nemtsov VA, Ogurtsov AY, Nechipurenko YD, Shabalina SA
PLoS One. 2010 . 5(4):e10180.
Korpal M, Kang Y
Eur J Cancer. 2010 May . 46(7):1232-40.
Lu X, Bennet B, Mu E, Rabinowitz J, Kang Y
J Biol Chem. 2010 Mar 26. 285(13):9317-21.
Lu X, Kang Y
Br J Cancer. 2010 Feb 2. 102(3):457-61.
Tiede BJ, Owens LA, Li F, DeCoste C, Kang Y
PLoS One. 2009 . 4(11):e8035.
Lu X, Kang Y
Cell Cycle. 2009 Dec . 8(23):3804-5.
Lu X, Kang Y
Cancer Res. 2009 Nov 15. 69(22):8536-9.
Hu G, Wei Y, Kang Y
Clin Cancer Res. 2009 Sep 15. 15(18):5615-20.
Lu X, Kang Y
J Biol Chem. 2009 Oct 16. 284(42):29087-96.
Hu G, Kang Y, Wang XF
J Mol Cell Biol. 2009 Oct . 1(1):3-5.
Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massagué J, Kang Y
Genes Dev. 2009 Aug 15. 23(16):1882-94.
Korpal M, Yan J, Lu X, Xu S, Lerit DA, Kang Y
Nat Med. 2009 Aug . 15(8):960-6.
Kang Y
Methods Mol Biol. 2009 . 568():7-19.
Wei Y, Hu G, Kang Y
Cell Cycle. 2009 Jul 15. 8(14):2132-3.
Lu X, Kang Y
Proc Natl Acad Sci U S A. 2009 Jun 9. 106(23):9385-90.
Korpal M, Kang Y
RNA Biol. . 5(3):115-9.
Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y
Cancer Cell. 2009 Jan 6. 15(1):9-20.
Korpal M, Lee ES, Hu G, Kang Y
J Biol Chem. 2008 May 30. 283(22):14910-4.
Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L
J Biol Chem. 2007 Sep 14. 282(37):26656-64.
Lu X, Kang Y
J Mammary Gland Biol Neoplasia. 2007 Sep . 12(2-3):153-62.
Kang Y
Breast Dis. . 26():129-38.
Li F, Tiede B, Massagué J, Kang Y
Cell Res. 2007 Jan . 17(1):3-14.
Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordón-Cardo C, Olshen AB, Gerald WL, Massagué J
Cold Spring Harb Symp Quant Biol. 2005 . 70():149-58.
Kang Y
J Cell Biochem. 2006 Aug 15. 98(6):1380-90.
Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massagué J
Proc Natl Acad Sci U S A. 2005 Sep 27. 102(39):13909-14.
Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massagué J
J Clin Invest. 2005 Jan . 115(1):44-55.
Kang Y, Massagué J
Cell. 2004 Aug 6. 118(3):277-9.
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA, Massagué J
Cancer Cell. 2003 Jun . 3(6):537-49.
Kang Y, Chen CR, Massagué J
Mol Cell. 2003 Apr . 11(4):915-26.
Xu L, Kang Y, Cöl S, Massagué J
Mol Cell. 2002 Aug . 10(2):271-82.
Chen CR, Kang Y, Siegel PM, Massagué J
Cell. 2002 Jul 12. 110(1):19-32.
Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM
Proc Natl Acad Sci U S A. 2002 Feb 19. 99(4):1888-93.
Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR
Mol Cell Biol. 2002 Jan . 22(1):245-56.
Coburn GA, Wiegand HL, Kang Y, Ho DN, Georgiadis MM, Cullen BR
Genes Dev. 2001 May 15. 15(10):1194-205.
Chen CR, Kang Y, Massagué J
Proc Natl Acad Sci U S A. 2001 Jan 30. 98(3):992-9.
Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White RL
Proc Natl Acad Sci U S A. 2000 Oct 24. 97(22):12085-90.
Kang Y, Bogerd HP, Cullen BR
J Virol. 2000 Jul . 74(13):5863-71.
Truant R, Kang Y, Cullen BR
J Biol Chem. 1999 Nov 5. 274(45):32167-71.
Kang Y, Bogerd HP, Yang J, Cullen BR
Virology. 1999 Sep 15. 262(1):200-9.
Kang Y, Cullen BR
Genes Dev. 1999 May 1. 13(9):1126-39.
Kang Y, Cullen BR
J Virol. 1998 Jul . 72(7):5502-9.
Kang Y, Blair WS, Cullen BR
J Virol. 1998 Jan . 72(1):504-11.