Ginty Lab
Johns Hopkins University and School of Medicine
We study the mechanisms of assembly and function of peripheral nervous system circuits underlying somatosensation and autonomic control of the body.
Field(s) of Research: Neurosciences
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Contact Us
Phone: 410-614-9496
Fax: 410-614-8423
725 N Wolfe Street
PCTB 1015
Baltimore, MD 21205
United States
Lab Members
Sarah Sarsfield
Lab Manager
Dori Reimert
Lab Technician
David Ginty
Kevin Wright
Anthony Harrington
Lishi Li
Yin Liu
Victoria Abraira
Research Associate
Amanda Zimmerman
Post-doctoral Fellow
Kathryn Lehigh
Graduate Student
Growth and Survival Signals Controlling Nervous System Development
The function of the nervous system is dependent upon trillions of neural connections. Not only must the organism generate neuronal numbers appropriate for the needs of targets being innervated, but it must also instruct these neurons to extend axons, elaborate dendrites, and generate synapses to establish proper connectivity. The goals of our laboratory are to identify key molecular events underlying axonal growth and survival and to establish the principles governing development of the vertebrate peripheral nervous system.

Our primary focus is on identification and characterization of key ligandÔÇôreceptor systems, and their intracellular signals, that control axonal growth, target field innervation and neuronal survival in the mammalian peripheral nervous system. Current projects in the laboratory address: 1) Mechanisms of nerve growth factor (NGF) control of gene expression in sensory and sympathetic neurons; 2) Mechanisms of long-range retrograde NGF signaling in neurons; 3) Axon guidance mechanisms that control establishment of peripheral nervous system circuits, and; 4) Identification of intracellular mediators of neuronal growth factor receptors that support axonal growth and survival. Our research projects make use of chemical, reverse and forward genetic strategies in the mouse, complemented with anatomical and biochemical approaches, enabling in vitro and in vivo analyses of neuronal growth factor mechanism and function.
Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD
J Neurosci. 2010 Apr 21. 30(16):5767-75.
Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD
Neuron. 2009 Dec 24. 64(6):841-56.
Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD
Nat Cell Biol. 2009 Dec 6. ():.
Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD
Neuron. 2009 Sep 10. 63(5):614-27.
Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD
Neuron. 2008 May 22. 58(4):532-45.
Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD
Nature. 2008 Apr 10. 452(7188):759-63.
Deppmann CD , Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD
Science. 2008 Apr 18. 320(5874):369-73.
Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD
Neuron. 2007 Jun 7. 54(5):739-54.
Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD
Mol Cell. 2006 Jan 20. 21(2):283-94.
Ramanan N, Shen Y, Sarsfield S, Lemberger T, Sch├╝tz G, Linden DJ, Ginty DD
Nat Neurosci. 2005 Jun . 8(6):759-67.
Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD
Neuron. 2005 Apr 7. 46(1):13-21.
Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD
Science. 2005 Jan 14. 307(5707):265-8.
Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD
J Neurosci. 2004 Oct 13. 24(41):9087-96.
Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD
Cell. 2004 Jul 23. 118(2):243-55.
Glebova NO, Ginty DD
J Neurosci. 2004 Jan 21. 24(3):743-51.
Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD
Dev Cell. 2003 Jul . 5(1):45-57.
Ye H, Kuruvilla R, Zweifel LS, Ginty DD
Neuron. 2003 Jul 3. 39(1):57-68.
Lonze BE, Riccio A, Cohen S, Ginty DD
Neuron. 2002 Apr 25. 34(3):371-85.
Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD
Neuron. 2002 Mar 14. 33(6):877-92.
Qian X, Ginty DD
Mol Cell Biol. 2001 Mar . 21(5):1613-20.
Kuruvilla R, Ye H, Ginty DD
Neuron. 2000 Sep . 27(3):499-512.
Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD
Science. 1999 Dec 17. 286(5448):2358-61.
Qian X, Riccio A, Zhang Y, Ginty DD
Neuron. 1998 Nov . 21(5):1017-29.
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD
Cell. 1997 Aug 22. 90(4):753-62.
Riccio A, Pierchala BA, Ciarallo CL, Ginty DD
Science. 1997 Aug 22. 277(5329):1097-100.