Phenazines affect biofilm formation by Pseudomonas aeruginosa in similar ways at various scales.

Ramos I, Dietrich LE, Price-Whelan A, Newman DK
Associated Labs:
Lars (Massachusetts Institute of Technology)
Res Microbiol. 2010 Feb 1. ():.
PMID: 20123017
Pseudomonads produce phenazines, a group of small, redox-active compounds with diverse physiological functions. In this study, we compared the phenotypes of Pseudomonas aeruginosa strain PA14 and a mutant unable to synthesize phenazines in flow cell and colony biofilms quantitatively. Although phenazine production does not impact the ability of PA14 to attach to surfaces, as has been shown for Pseudomonas chlororaphis[9,8], it influences swarming motility and the surface-to-volume ratio of mature biofilms. These results indicate that phenazines affect biofilm development across a large range of scales, but in unique ways for different Pseudomonas species.

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