Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins.
(Massachusetts Institute of Technology)
Biochim Biophys Acta. 2003 Aug 18. 1641(2-3):111-9.
SNARE proteins function at the center of membrane fusion reactions by forming complexes with each other via their coiled-coil domains. Several SNAREs have N-terminal domains (NTDs) that precede the coiled-coil domain and have critical functions in regulating the fusion cascade. This review will highlight recent findings on NTDs of syntaxins, the longin domain of VAMP proteins and SNAP-23/25 homologues in yeast. Biochemical and genetic experiments as well as the resolution of several NMR and crystal structures of SNARE NTDs shed light on their diverse function.